358.72% oral bioavailability
A small molecule nano-prodrug synthesized via amide reaction between chlorambucil and star-shaped ortho esters, which dynamically transitions from large to small size in response to pH changes from the gastrointestinal tract to tumors, overcoming multiple physiological barriers for oral chemotherapy.
Liu, Xin · Wang, Zhexiang · Xiaodie, Ren · Chen, Xinyang · Jinjin, Tao · Yuanhui, Guan · Xuefeng, Yang · Tang, Rupei · Yan, Guoqing
Asian Journal of Pharmaceutical Sciences 2023
Significant tumor growth inhibition
Reduced side effects