Alginate/Collagen Hybrid Hydrogel

Preserves chondrocyte phenotype

Tuning the G/M ratio of alginate provides suitable matrix conditions for chondrocyte culture.

Zheng, Guoshuang · Xue, Chundong · Cao, Fang · Hu, Minghui · Xie, Hui · Yu, Weiting · Zhao, Dewei

Frontiers in Bioengineering and Biotechnology 2023

Advantages

Chondrocytes on Mid-G/M hydrogels exhibit better viability

Chondrocytes on Mid-G/M hydrogels show better phenotype preservation

Increased expression of SOX9, COL2, and aggrecan on Mid-G/M hydrogels

Decreased expression of RAC and ROCK1 on Mid-G/M hydrogels