Targeted cardiac anti-fibrosis
A cell therapy that locally reprograms the cardiac immune microenvironment to suppress pathological fibrosis and preserve function without systemic immunosuppression.
Li, Xiaoying · Li, Jiamin · Li, Guohua · Zhu, Lisheng · Guo, Cheng · Li, Huanqiang · Hao, Lin · Xiaoqian, Hong · Liu, Ye · Zhong, Zhiwei · Chen, Yize · Zhao, Jing · Wang, Lingjun · Chen, Qiming · Ni, Cheng · Ke, Changle · Shaohui, Shi · He, Junhua · Wu, Yan · Kong, Minjian · Chen, Qi · Li, Huajun · Zhang, Yu · Sun, Jianzhong · Zhao, Chengchen · Yu, Lili · Xu, Yang · Hu, Xinyang
Nature 2026
Reduced cardiac fibrosis and improved perfusion and contractile function in a non-human primate model of myocardial infarction
Reduced inflammatory cardiac fibrosis and improved perfusion and contractility in mouse models of ischaemia-reperfusion injury, myocardial infarction and pressure overload