Tumor-specific activation
These nanoparticles convert low-toxicity V(IV) prodrugs into active V(V) in response to reactive oxygen species in the tumor microenvironment, enabling targeted inhibition of Na/K-ATPase for enhanced anticancer efficacy with minimal systemic toxicity.
Li, Yifan · Wang, Jian · Tang, Yujing · Yu, Yingjie · Lv, Yitong · Li, Wenzhe · Zhang, Ming
Nanoscale 2023
Near-infrared photothermal conversion enables mild hyperthermia at tumor site
Negligible toxicity to normal tissues