Linkage in Minutes
A new C-SuFEx linkage that couples sulfonimidoyl fluorides with organotrifluoroborates in minutes, forming diverse S(VI)–C bonds and compatible with sensitive functional groups in natural products and pharmaceuticals.
Zeng, Daming · Wang, Ming · Jiang, Xuefeng
Nature Communications 2024
Linkage achieved in minutes
Forms S(VI)–C(alkyl), S(VI)–C(alkenyl), and S(VI)–C(aryl) bonds
Compatible with sensitive functional groups in molecules such as valdecoxib, celecoxib, and diacetonefructose