Self-catalytically Enhanced mPTT
With dual-active catalytic centers (Fe-Cu) and near-infrared photothermal properties, it generates hydroxyl radicals in situ to disrupt heat shock protein structure and restore tumor cell sensitivity to mild photothermal therapy.
Xuegang, Niu · Zhu, Yang · Chenyu, Ding · Jing, Ma · Penghui, Wei · Yuanxiang, Lin · Wenhua, Fang · Qiu, He · Chunwang, Li · Cheng, Junjie · Zou, Jianhua · Lin, Lisen · Xiaoyuan, Chen · Kang, Dezhi
Advanced Functional Materials 2023
Achieved significant tumor elimination in a U87MG murine tumor model
Depleted intracellular glutathione and promoted lipid peroxidation, triggering tumor ferroptosis
Possesses dual-active catalytic centers (Fe-Cu) and near-infrared photothermal properties