Biomimetic Nano-Heterojunction

ROS Storm Clears Biofilms

A biomimetic nano-heterojunction overcomes photodynamic therapy bottlenecks in hypoxic biofilms by enabling NIR-triggered oxygen self-supply and efficient electron–hole separation, markedly enhancing bacterial killing and improving tissue healing.

Zhengcai, Guo · Zhang, Rui · Li, Yi · Zhiling, Chen · Tao, Wang · Mingyu, Wang · Wang, Xiaohong · Cao, Yang · Jinchun, Tu · Chen, Delun · Wang, Yang · Wu, Qiang

Chemical Engineering Journal 2025

Advantages

Specifically targets bacteria via IsdB

Fe3+-mediated glutathione depletion and Fenton reaction

Achieves rapid bacterial clearance

Significantly improves hypoxia of biofilm microenvironment