Paclitaxel-Loaded Tumor Suppression
Fused from MSC exosomes and folate-targeted liposomes, it activates antitumor immunity and remodels the tumor microenvironment.
Wang, Xuan · Li, Dongdong · Li, Gaotian · Yang, Yi · Bian, Lijun · Jingying, Zhou · Wu, Yongge · Chen, Yan
International Journal of Molecular Sciences 2024
Significantly suppressed tumor growth in CT26 tumor-bearing mouse model in vivo
Activated CD4+ and CD8+ T cells
Reduced M2 type tumor-associated macrophages (TAMs) and polarized them towards M1 type
Decreased regulatory T cells (Tregs)