pH-responsive high transfection
Using MC3 ionizable lipid, it forms inverted hexagonal phase in acidic environment to promote membrane perturbation, achieving the highest transfection efficiency.
Li, Ke · Panqi, Song · Ye, Ru Yi · Li, Hao · Tian, Qiang · Duan, Jialin · He, Xiao-Peng · Li, Na
Journal of Controlled Release 2026
MC3-mRNA-LNPs achieved the highest cellular transfection efficiency
MC3 forms inverted hexagonal phases (HII) that facilitate LNPs membrane perturbation
mRNA-LNPs formed by three FDA-approved ionizable lipids (ALC-0315, DLin-MC3-DMA, SM-102)