Axially Chiral Arylpyrroles

First mono-substituted 3-arylpyrrole atropisomers

Copper-catalyzed atroposelective diyne cyclization constructs mono-substituted 3-arylpyrrole atropisomers for the first time, offering a new synthetic route to five-membered axially chiral biaryls via vinyl cations.

Chen, Bo · Liu, Lin · Chen, Can · Liu, Xi · Zhou, Bo · Lu, Xin · Xu, Zhou · Wu, Ye

Angewandte Chemie - International Edition 2023

Specifications

收率高

{'zh': '99', 'en': ''} %

Advantages

First synthesis of mono-substituted 3-arylpyrrole atropisomers

First atroposelective diyne cyclization

First atropisomer construction via vinyl cations