Metamifop Polymorph A

Higher uptake, slower metabolism

A more thermodynamically stable Metamifop polymorph with higher ACCase inhibition, sustaining high steady-state concentration in weeds for prolonged target inhibition.

Zhao, Qi · Du, Shichao · Yang, Sheng Tao · Xue, Fumin · Liu, Weitang · Hu, Ruonan

Journal of Hazardous Materials 2026

Specifications

ACCase inhibitory activity difference

{'zh': '0.04', 'en': '0.04'} mol·min⁻¹·mg⁻¹

Binding affinity difference

{'zh': '7', 'en': '7'} kcal·mol⁻¹

Threshold for inhibition of nitrogen-fixing bacteria

{'zh': '100', 'en': '100'} mg·L⁻¹

Advantages

Higher activity

Polymorph A exhibits 0.04 mol·min⁻¹·mg⁻¹ higher ACCase inhibitory activity than polymorph B, leading to better weed control.

More stable

Polymorph A shows superior thermodynamic stability, beneficial for storage and formulation.

Faster absorption

Polymorph A has a higher absorption rate than polymorph B in weeds, reaching effective concentration faster.

Slower metabolism

Polymorph A has a lower metabolic rate than polymorph B, sustaining drug concentration for longer.

Applications

• weed control：Leverage polymorph A's high activity and sustained inhibition for better weed control.
• herbicide formulation：Polymorph A's higher thermodynamic stability improves formulation storage stability and efficacy.
• crop protection：Lower environmental risk enables safe weed management in crop protection.