pH/GSH Dual-Responsive Nanoparticles

Enhanced Type I PDT for Hypoxic Tumors

Acid-triggered disassembly releases a NO donor; GSH depletion couples with peroxynitrite generation to enable oxygen-independent radical killing.

Zou, Jianhua · Li, Zheng · Zhu, Yang · Yucen, Tao · Qing, You · Fangfang, Cao · Wu, Qinghe · Wu, Min · Cheng, Junjie · Zhu, Jianwei · Xiaoyuan, Chen

Bioactive Materials 2024

Advantages

achieved successful tumor eradication

NIR-II fluorescence imaging guided therapy