Photocontrolled Drug-Release Nanoplatform

Dual NIR-II Laser Trigger

Two sequential NIR-II laser irradiations achieve drug release and fluorescence monitoring of therapeutic outcomes, providing an imaging-based prognostic indicator for precise AD treatment.

Qiu, Zhili · Guojun, Cao · Shanrong, Lv · Dehong, Yu · Jingjing, Fu · Yan, Hanrong · Li, Yuting · Zhou, Peng · Wu, Xiunan · Liu, Zhao · Gao, Fenglei

Chemical Engineering Journal 2023

Advantages

1064 nm laser first irradiation achieves light-controlled delivery

Upon secondary irradiation, AβO and Ca2+ trigger DNA nanomachine to restore fluorescence

Degree of calcium overload negatively correlated with treatment outcome