Ruthenium(II) Topoisomerase Inhibitor

Mitochondria-targeted anticancer

Targets mitochondria to inhibit topoisomerase I and induce cancer cell apoptosis, with antiproliferative activity superior to cisplatin.

Tang, Hong · Guo, Xinhua · Zhu, Xiudeng · Huang, Zunnan · Chen, Lanmei · Chen, Jincan

Journal of Inorganic Biochemistry 2023

Specifications

IC

{'zh': '3.6', 'en': '3.6'} μM

Advantages

Preferentially accumulate in mitochondria

Induce mitochondrial membrane depolarization

Damage mitochondrial DNA and inhibit its synthesis