Asymmetric Amination Reagent

Inert Bond Activation

A solubility-control strategy enables thermodynamically unfavorable cleavage of unstrained C(sp3)-C(sp3) bonds and C-N bond formation with high enantioselectivity.

Liu, Yang · Chen, Wei · Yang, Xiang · Hartwig, John F. · He, Zhitao

Journal of the American Chemical Society 2024

Advantages

good yields

high enantioselectivity