ROS-responsive dissociation
Wrapped with macrophage membrane, these platinum nanozyme clusters target renal inflammation and neutralize pro-inflammatory cytokines, and can dissociate into ultrasmall platinum nanoparticles under the high ROS conditions specific to acute kidney injury to scavenge free radicals, with eventual excretion through renal filtration.
Qu, Ying · Chu, Bingyang · Pan, Meng · Yuan, Liping · Lu Yi, · Qian, Zhiyong
Biomaterials 2024
In a mouse model of ischemia/reperfusion-induced AKI, systemic injection of MM-PtNCs significantly reduced renal damage and restored kidney function
MM-PtNCs effectively prevented the progression of AKI to chronic kidney disease
PtNCs exhibit free radical scavenging ability and catalase-like activity
PtNCs dissociate into ultrasmall platinum nanoparticles under AKI-specific ROS conditions and are eventually excreted through the renal filtration system