Lung-Targeted Protein Delivery
Thioketal-containing lipid nanoparticles identified by mass spectrometry-assisted screening enable selective delivery of functional proteins to the lung in vivo.
Liu, Ji · Zhang, Yangyang · Tianyu, Ma · Zhao, Zhenwen · Wang, Ming
Nano Letters 2026
combinatorial library of 46 thioketal-containing biodegradable lipids
receptor-mediated uptake by pulmonary endothelial cells
validation across multiple animal species
activate MAPK signaling, mitigating ferroptosis and inflammatory injury