Drives Pyrimidine Synthesis
Direct activation of the key enzyme CAD links glycolysis to nucleic acid synthesis, offering a new metabolic target for proliferating cells.
Cai, Yongfeng · Ma, Qian · Yang, Qiuhua · Cao, Yapeng · Zhou, Yaqi · Liu, Zhiping · Xu, Jiean · Quan, Junming Min · Zhang, Liang · Wang, Rui · Jiang, Xuejun · Xiao-Xiao, Liu · Ouyang, Kunfu · Han, Zhen · Liu, Jikui · Wang, Tao · Zhang, Chunxiang · Weintraub, Neal L. · Fulton, David J.R. · Mei, Hong · Li, Zigang · Huo, Yuqing
Cell Reports 2025
Promotes cell proliferation
Increases RNA and DNA production
Enhances de novo pyrimidine synthesis