Dual-function alignment & pH sensing
Simultaneously guides cell alignment and monitors extracellular pH via SERS, revealing microenvironment heterogeneity.
Wu, Xiaoyu · Yang, Kai · Shan, He · Zhu, Feng · Liu, Bohua · Sun, Chongling · Pang, Wei · Wang, Yanyan
Journal of Colloid and Interface Science 2023
Achieves contact guidance and cell morphology changes
pHe obtained from SERS spectral changes during cell alignment
pHe near cytoplasm lower than near nucleus
MSCs show dramatic response with different morphology and increased pHe