Regenerative recovery after chronic injury
As a reserve population, Setd4+ cells survive chronic injury and are activated via chromatin remodeling to initiate liver regeneration.
Jia, Zheng · Zhuang, Tian · Ri-Sheng, Yang · Yun-Wen, Gu · Yi-Zhe, Zeng · Christopher, Wood · Yang, Shu · Yang, Weijun
Journal of Hepatology 2025
Survive under chronic injury
Activate to proliferate and facilitate regenerative recovery
Dormancy maintained by H4K20me3-mediated heterochromatin
Activation triggered by chromatin accessibility remodeling