Disrupts Cu/Fe Homeostasis
A nanoplatform that simultaneously induces cuproptosis and ferroptosis while activating antitumor immunity.
Li, Xiang · Wang, Ke · Liu, Zhao · Sun, Rongrong · Gao, Fenglei
ACS Nano 2026
Enhances ZNT1 expression to increase Cu2+ influx
Silences ATP7A to inhibit Cu2+ efflux, inducing cuproptosis
Mitochondrial Fe2+ release combined with Co2+-induced free Fe2+ generates an "Fe2+ storm"
Activates immunogenic cell death and the cGAS-STING pathway