No affinity loss
DNA superstructures composed of tandem repeating aptamers achieve strong cooperative ligand binding while retaining the binding affinity of the parent aptamer.
Yin, Qingxin · Zhao, Dan · Chang, Yangyang · Liu, Bo · Liu, Yi · Liu, Meng
Angewandte Chemie - International Edition 2023
exhibit highly cooperative binding to both small molecules and proteins
without loss of binding affinities of their parent aptamers