Targeted combination therapy for colorectal cancer
Genetically engineered cell membrane-coated nanoparticles with enhanced CD47 affinity, prolonged circulation, and synergistic photothermal and glycolytic inhibition.
Yang, Yun · Liu, Qingya · Meng, Wang · Li, Lang · Yu, Yan · Pan, Meng · Hu, Danrong · Chu, Bingyang · Qu, Ying · Qian, Zhiyong
Signal Transduction and Targeted Therapy 2024
Significantly prolonged blood circulation time
Significantly enhanced macrophage phagocytosis of colorectal cancer cells
Significantly inhibited glycolysis, reduced ATP and lactate levels
Photothermal therapy significantly enhanced antitumor efficacy