GSD-16-24 small-molecule inhibitor

Targets α-syn fibril disordered region

Targets the C-terminal disordered region of α-synuclein fibrils, blocking their binding to receptors such as LAG3 and RAGE to alleviate Parkinson's disease pathology.

Zhang, Shenqing · Xiang, Huaijiang · Tao, Youqi · Li, Juan · Shuyi, Zeng · Xu, Qianhui · Lv, Shiran · Cheng, Yan · Zhang, Shengnan · Sun, Bo · Li, Dan · Xiang, Shengqi · Tan, Li · Liu, Cong

Journal of the American Chemical Society 2024