Cu Single-Atom-Modified Defective WO₃₋ₓ Nanosheets

Sonodynamic tumor ablation

Synergistic Cu single atoms and oxygen vacancies amplify ultrasound-induced reactive oxygen species generation, outperforming WO₃₋ₓ and other metal-modified variants for efficient sonodynamic tumor therapy.

Zhou, Zhan · Wang, Tao · Xu, Hao · Cui, Lin · Baoli, Xue · Zhao, Xinshuo · Shilong, Yu · Li, Hai · Qin, Yong · Zhang, Jiankang · Ma, Lufang · Liang, Ruizheng · Tan, Chaoliang

Advanced Materials 2024

Advantages

Cu-WO₃₋ₓ exhibits much higher activity for ultrasound-induced reactive oxygen species production than WO₃₋ₓ and Cu SA-decorated WO₃

Cu-WO₃₋ₓ can quickly kill cancer cells in vitro and effectively eradicate tumors in vivo under US irradiation