Sensitizes PD-1 Therapy
Inhibiting PSAT1 phosphorylation at S337 enhances IFNγ-induced ferroptosis and improves response to PD-1 blockade in triple-negative breast cancer.
Zheng, Peixiang · Hu, Zhiqiang · Yuli, Shen · Gu, Lina · Ouyang, Yuan · Yuran, Duan · Guimei, Ji · Bofei, Dong · Lin, Yanni · Ting, Wen · Tian, Qi · Yueru, Hou · Zhou, Qimin · Sun, Xue · Xiaohan, Chen · Luo, Shudi · Shiqi, Wu · Li, Min · Liwei, Xiao · Wu, Qingang · Meng, Ying · Guijun, Liu · Wang, Zheng · Bai, Xueli · Shengzhong, Duan · Ding, Yuan · Yuhao, Wang · Liu, Xiaoguang · Lu, Zhimin · Xiaohong, Wu · Tang, Zhiyuan · Xu, Daqian
Nature Chemical Biology 2025
Blocking PSAT1 pS337 enhances IFNγ-induced ferroptosis and improves PD-1 antibody efficacy
Reconstitution of PSAT1 S337A or GPX4 P159A promotes ferroptosis and suppresses TNBC progression
PSAT1-mediated GPX4 hydroxylation correlates with poor immunotherapy outcomes in TNBC patients