Lyophilizable, thermostable, long stable
Coated with glycol chitosan via microfluidics, it remains adjuvant-active after autoclaving and lyophilization, while inducing balanced humoral and cellular immunity—a capability absent in conventional aluminum adjuvants.
Jingying, Zhou · Bian, Lijun · Li, Dongdong · Li, Gaotian · Wang, Xuan · Sun, Bo · Jiang, Chunlai · Chen, Yan · Zhang, Yong
Advanced healthcare materials 2026
Withstands autoclaving and freeze-drying without significant physicochemical changes in the presence of trehalose (GCS/Al weight ratio >4:1)
Lyophilized form remained stable for 15 months at room temperature
G7-A1 with HPV16 L1 VLPs elicited higher neutralizing antibody titers and balanced IgG1/IgG2c ratio
Combining G7-A1 with MF59-like emulsion or C-di-AMP enhanced antigen-specific immunity, memory T cell responses, and dendritic cell activation