N-Alkylated Chitosan Nanofiber Membrane

Rapid liver hemostasis without adhesion

Doping octadecyl-grafted N-alkylated chitosan into chitosan/PEO electrospun membrane endows it with rapid blood coagulation and hemophobic surface, forming stable clots and allowing easy removal without secondary bleeding.

Liu, Tao · Ding, Sheng · Wen, Zhang · Meng, Xin · Li, Fan

International Journal of Biological Macromolecules 2023

Advantages

Whole blood clotting time 58.8±2.2 s

Significantly lower than chitosan/PEO membrane (67±3.5 s) and medical gauze (86.7±0.6 s)

Promotes fibroblast proliferation