Tunable Habit
Combined polymer additives and ultrasound modulate crystallization to transform needle-like habit into block, plate, and rice-shaped crystals, improving processability and bioavailability of a poorly water-soluble drug.
Wang, Yan · Cai, Lun · Xue, Fumin · Chen, Hui · Gong, Junbo · Du, Shichao
Ultrasonics Sonochemistry 2023
Block-like crystals obtained with PVP
Plate-like crystals with shorter aspect ratio under ultrasound
Rice-shaped crystals with further reduced average particle size using PVP and ultrasound
PVP acts as strong nucleation and growth inhibitor