Oxygen Self-Supplying Nanocomposite

Penetrates biofilms, kills intracellular MRSA

Responds to the bacterial microenvironment to release oxygen and polarize macrophages via photodynamic immunomodulation, eradicating planktonic, biofilm, and intracellular MRSA simultaneously.

Chen, Xiangjun · Xiao, Liu · Weiwei, Li · Xuanxiang, Zhai · Xiaoyi, Shi · Wenting, Li · Hong, Wei

Chemical Engineering Journal 2025

Advantages

Releases H₂O₂ and O₂ in acidic and hyaluronidase-overexpressing bacterial microenvironment

Antibacterial effect against planktonic, biofilm, and intracellular bacteria verified in vitro and in vivo

Good biocompatibility demonstrated in vivo