Depletes sialic acid to curb bone metastasis
Sustained depletion of sialic acid in the acidic bone metastatic niche concurrently inhibits osteoclast fusion and cancer cell migration, disrupting the tumor-osteoclast cycle while promoting bone microarchitecture restoration.
Zhengrong, Chen · Zhang, Jie · Tan, Jiulin · Dai, Qijie · Luo, Fei · Xu, Jianzhong · Dou, Ce
Acta Biomaterialia 2026
Significantly prolonged survival
Effectively prevented secondary pulmonary metastasis
Substantial attenuation of tumor-induced osteolysis