COF-derived photocatalytic artificial oxidase

Robust catalysis under natural light

A covalent organic framework-derived photocatalytic artificial oxidase that efficiently catalyzes TMB oxidation under natural light, enabling label-free colorimetric detection of α-glucosidase activity for high-throughput screening of active inhibitors in complex natural product extracts.

Hui, Yuan · Liu, Quanxia · Xiaoxuan, Fan · Yang, Lingling · Keshuai, Liu · Xin, He · Wang, Jing · Ma, Xueqin · Chen, Guoning

Talanta 2026

Specifications

Linear range

{'zh': '', 'en': '-30'} μg mL⁻¹

IC values

{'zh': '5.62', 'en': '5.62'} μM

Advantages

Robust catalytic capability toward TMB under natural light excitation

Successful identification of bioactive extracts from 25 natural product candidates