Blocks DHEA Conversion
Knockdown of hepatic KLF9 suppresses intrahepatic androgen conversion, alleviating hyperandrogenism in PCOS and providing a novel liver-ovary axis-targeted entity.
Wang, Jing · Yan, Xiurui · Zhang, Yujie · Zhang, Yinliang · Ha, Chunfang · Hu, Rong · Chang, Yongsheng · Zhang, Yaolin · Fan, Heng
Advanced Science 2025
Hepatocyte-specific Klf9 ablation significantly alleviates DHEA-induced PCOS progression
Hepatic Klf9 transgenic mice spontaneously exhibit PCOS-like phenotypes