Engineered UNG Protein

Direct thymine editing

A Deinococcus radiodurans UNG mutant fused with nCas9 enables efficient and low-toxicity thymine base editing, restoring IDUA enzyme activity in Hurler syndrome cells.

Yi, Zongyi · Li, Jiayi · Tang, Huixian · Yu, Ying · Wei, Wensheng

Nature Communications 2024

Specifications

源位点胸腺嘧啶编辑效率最高

{'zh': '55', 'en': ''} %

Advantages

Minimal cellular toxicity

High editing specificity

Significantly restores IDUA enzyme activity in cells from Hurler syndrome patients