cis-Selective Allylic Trifluoromethylation Reagent

Unique cis-enamide products

Overcomes thermodynamic bias to selectively produce cis-trifluoromethylated enamides, offering a novel fluorinated building block for pharmaceuticals and materials.

Chen, Xiaoyun · Han, Ying · Sun, Qiu · Yu, Huaguang · Hou, Hong · Yan, Changhao · Zhu, Shaoqun

Journal of Organic Chemistry 2025

Advantages

moderate to good isolated yields

trifluoromethylpyridinium salt as CF3 source

dual photoredox/copper catalysis