Lysosomal escape boosts efficacy
Co-loaded with an angiogenesis inhibitor and a STING agonist, these nanoparticles trigger lysosomal escape for synergistic anti-tumor immunity, offering a novel strategy against peritoneal metastatic colorectal cancer.
Meng, Wang · Yutong, Qian · Li, Yicong · XiCheng, Li · Mei, Zhu · Hu, Danrong · Ran, Li · Pan, Meng · Yang, Yun · Jianan, Li · Qian, Zhiyong
Acta Pharmaceutica Sinica B 2026
Significantly inhibit tumor proliferation
Normalize pathological vasculature
Reprogram the immunosuppressive microenvironment
Reduce tumor burden and ascites