Virus-mimetic cascade delivery
Mimicking viral infection in living cells, it sequentially achieves targeting, hydrolysis, and morphological transformation for efficient co-delivery of drug and peptide into cancer cells for synergistic therapy.
Feng, Tian · Chen, Guo · Wu, Chunxia · Liu, Xin · Zeyu, Zhang · Wang, Hao · Li, Gongyu · Yu, Zhilin
Angewandte Chemie - International Edition 2024
Targets cancer cells secreting Gal-1 and overexpressing β-galactosidase
In situ formation of nanofibers in cytoplasm
Enhanced tumor accumulation and retention, suppressing tumor growth