Self-Reinforcing Chemodynamic Therapy
Overcomes insufficient membrane damage in conventional CDT by amplifying lipid peroxidation via modulating cell membrane unsaturation
Zhu, Yang · Peng, Gong · Jun, Wang · Cheng, Junjie · Wang, Wenyu · Cai, Huilan · Ao, Rujiang · Hongwei, Huang · Meili, Yu · Lin, Lisen · Xiaoyuan, Chen
Angewandte Chemie - International Edition 2023
Oleanolic acid-loaded iron single-atom catalyst embedded in hollow carbon nanospheres and encapsulated by erythrocyte membrane
Fe-SAC catalyzes conversion of endogenous hydrogen peroxide into hydroxyl radicals
Released oleanolic acid enriches cellular membranes with polyunsaturated fatty acids
Achieves lipid peroxidation amplification-enhanced chemodynamic therapy