TGN-020/Peptide Conjugates

Sustained AQP4 inhibition

A compound that enzyme-instructedly self-assembles into nanofibers binding AQP4 multivalently for glioma chemotherapy sensitization.

Gao, Yuan

ACS Nano 2026

Advantages

Sustained inhibition

The nanofibers bind AQP4 multivalently, resulting in sustained inhibition that overcomes the transient effect of monomeric TGN-020.

Selective for glioma cells

Self-assembly occurs selectively on the plasma membrane of glioma cells expressing both alkaline phosphatase and AQP4.

Chemosensitization

Occlusion of AQP4 enhanced the sensitivity of glioma xenografts to temozolomide in a subcutaneous mouse model.

Applications

• Glioma targeted therapy：Enhances temozolomide efficacy against glioma
• Nanomedicine delivery：In situ assembled nanofibers enable multivalent targeting
• AQP4 biosensing：Multivalent AQP4 binding enables sensitive detection