Alleviates Aging and Inflammation
Lentiviral delivery of shRNA targeting ARID5A in the myocardium mitigates aging-related inflammation and enhances cardiac function, offering a direct intervention for cardiac aging.
Fan, Yanling · Zheng, Yandong · Xu, Gang · Hu, Jianli · Ji, Qianzhao · Lei, Jinghui · Li, Lan · Wang, Xing · Xu, Xi · Wang, Cui · Wang, Si · Ma, Shuai · Song, Moshi · Jiang, Wenjian · Zhu, Junming · Wang, Jiangang · Yang, Ying · Zhu, Guodong · Tian, Xiaoli · Zhang, Hongjia · Song, Weihong · Yang, Jiayin · Yao, Yan · Liu, Guanghui · Qu, Jing · Zhang, Weiqi
Nature Cardiovascular Research 2025
Cardiac function significantly enhanced in aged mice after intramyocardial injection
Significantly mitigated inflammatory and aging phenotypes