Restores aged antitumor immunity
A small-molecule inhibitor targeting BFAR that rescues antitumor activity of aged CD8+ T cells by restoring CD8+ tissue-resident memory T cell generation in the tumor microenvironment and overcomes anti-PD-1 resistance.
Pei, Siyu · Wang, Hui · Shi, Jian Hong · Huang, Jia · Tian, Yu · Zhang, Sulin · Xu, Jing · Wang, Congyi · Wei, Lu · Luo, Qingquan · Ni, Zhiyu · Zheng, Mingyue · Xiao, Yichuan
Nature Aging 2024
iBFAR2 treatment rescues antitumor activity of aged CD8+ T cells
Efficiently inhibits tumor growth in aged CD8+ T cell transfer and anti-PD-1-resistant mouse tumor models