CsPbBr₃@SiO₂ fluorescent probe

down to 0.54 CFU/mL

A perovskite quantum dot-based stable fluorescent probe enabling highly sensitive dual-mode detection of S. aureus in complex food matrices.

Zhang, Sai · Zhang, Yu · Kewei, Feng · Yane, Luo · Junfeng, Yao · Yuan, Yahong · Yue, Tianli · Sheng, Qinglin

Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy 2026

Specifications

LOD (fluorescent mode)

{'zh': '0.54', 'en': '0.54'} CFU/mL

LOD (colorimetric mode)

{'zh': '103', 'en': '103'} CFU/mL

Detection range

{'zh': '1-10⁶', 'en': '1-10⁶'} CFU/mL

Advantages

Less misjudgment

Provides both colorimetric and fluorescent signals in one system, allowing cross-validation.

Label-free

Relies on the inner filter effect between gold nanoparticles and quantum dots to quench fluorescence, requiring no recognition molecule modifications.

Stable fluorescence

SiO₂ coating significantly improves the stability of perovskite quantum dots, making the probe practical for detection.

Applications

• S. aureus detection：The 0.54 CFU/mL fluorescent LOD enables trace detection of S. aureus in food.
• food safety testing：Validated on various food samples, suitable for on-site screening.
• fluorescent sensing：SiO₂-coated perovskite QDs solve fluorescence stability issues, enabling reliable fluorescent readout.
• dual-mode sensor：Dual-mode cross-validation eliminates single-signal artifacts, giving more reliable results.