Engineered Bacterial Nanocomposite

Turns cold tumors hot

An anaerobic engineered bacterium coated with polydopamine and conjugated with chitosan oligosaccharide nanoparticles that eradicates tumors in a triple-negative breast cancer model with a single injection.

Xuanxiang, Zhai · Xiaoyi, Shi · Liu, Xiao · Li, Wenting · Chen, Xiangjun · Hong, Wei

Advanced Science 2025

Advantages

Tumors eradicated after a single injection and laser irradiation

No metastasis observed

No discernible side effects