One Agent, Triple Action
An ER-targeted photodynamic agent that induces tumor pyroptosis while suppressing immunosuppressive pathways, offering a novel multifunctional photosensitizer for solid tumor immunotherapy.
Zeng, Shuang · Chen, Chen · Maojun, Jiang · Li, Xin · Liu, Xiaosheng · Zhihan, Guo · Hao, Yifu · Zhou Danhong, · Kim, Heejeong · Kang, Heemin · Wang, Jingyun · Chen, Qixian · Li, Haidong · Peng, Xiaojun · Yoon, Juyoung
Advanced Science 2025
Achieves type I photodynamic therapy under hypoxia
Significantly induces pyroptosis via caspase-1/GSDMD pathway
Inhibits COX-2 downstream HIF-1α, PGE2, and VEGF pathways