Halts NASH fibrosis
This unit uncovers an intrahepatic CREBZF-osteopontin signaling axis that acts as a checkpoint in steatosis-to-NASH progression, driving fibrosis via paracrine activation of hepatic stellate cells and offering a new therapeutic target for NASH.
Ding, Guohui · Sun, Xiaoyang · Li, Wenjin · Zhang, Haibing · Li, Hong · Xiao, Dongguang · Zhang, Cuiying · Qin, Jun · Gao, Xin · Dai, Xiaozhen · Fu, Wenguang · Xu, Yong · Li, Yu
Hepatology 2023
CREBZF deficiency attenuated liver injury, fibrosis, and inflammation in diet-induced mouse models of NASH
CREBZF increases HSC activation and fibrosis by stimulating extracellular matrix protein osteopontin
Adeno-associated virus-mediated rescue of osteopontin restored HSC activation, liver fibrosis, and NASH progression in CREBZF-deficient mice