Peptide Coacervates

Boosts cytosolic delivery

A class of peptides that efficiently facilitate cytosolic delivery of STING agonists by forming coacervates, enhancing STING activation for cancer immunotherapy.

Zheng, Wenlv · Tang, Wei · Wang, Jianzheng · Wu, Dan · Wang, Xiaoquan · Quan, Junming Min

Vaccines 2026

Advantages

Self-assembles into coacervates

Mixing the peptide with cGAMP forms coacervates spontaneously, eliminating complex formulation steps.

Suppresses tumor growth

Intratumoral administration of Sti3-4A and cGAMP effectively suppressed tumor growth and promoted antitumor immune response.

Enhances vaccine immunity

Conjugating antigen peptides with Sti3-4A improves APC maturation, antigen cross-presentation, and T cell responses to peptide antigens.

Applications

• Cancer immunotherapy：Delivers STING agonists to activate antitumor immunity and suppress tumors upon local administration.
• Intracellular delivery：Peptide coacervates mediate efficient cytosolic entry of cGAMP and other agonists, bypassing pharmacokinetic limitations.
• Vaccine adjuvant：Conjugation with antigen peptides enables co-delivery that markedly enhances APC maturation and T cell responses.