PtAu/GOx Composite Nanozyme

Photothermal-Cascade Synergy

A tripartite morphological-crystallographic-electronic optimization integrates photothermal conversion with cascade catalysis on a single nanozyme, utilizing endogenous glucose to continuously generate highly cytotoxic radicals for enhanced antitumor efficacy.

Xu, Sun · Long, Zhang · Jiaxin, Niu · Gongxian, Sun · Hangyang, Ling · Zhang, Rui · Shuyu, Chen · Hairui, Deng · Kong, Xiangdong · Zhuo, Xiaolu · Zhang, Han

Materials Today Bio 2026

Advantages

Efficient cascade catalysis

High surface area for active site exposure, high/low-index hybrid facets for optimized substrate adsorption, and Au-Pt charge transfer to regulate d-band centers tripartitely enhance multi-enzyme-like catalytic activities, driving an efficient cascade catalytic cycle.

Superior NIR-II photothermal conversion

The composite nanozyme has superior photothermal conversion performance under second near-infrared laser irradiation, synergistically achieving photothermal-augmented tumor cascade catalytic therapy.

Validated antitumor efficacy

Both in vitro and in vivo experiments validate the enhanced antitumor efficacy of the PtAu/GOx nanozyme through the synergistic optimization, supporting further clinical translation.

Applications

• Combined Tumor Therapy：Synergize photothermal therapy with cascade catalytic ROS generation for enhanced combined antitumor efficacy.
• TME-Responsive Theranostics：Exploit tumor microenvironment endogenous glucose to trigger cascade reactions for responsive therapy.
• Nanomedicine Delivery：Serve as a nanocarrier delivering enzymatic and photothermal functions to the tumor site.
• Nanozyme Catalytic Medicine：Employ multi-enzyme activities to convert glucose into highly cytotoxic hydroxyl radicals.