Asymmetric Formal sp²-Hydrocarbonation Catalytic System

Unlocks Inert sp² Carbon Nucleophiles

A cascade strategy efficiently achieves formal sp²-hydrocarbonation of dienes and alkynes, synthesizing various challenging stereogenic molecules.

Zi-Yang, Chen · He, Zhitao

Nature Communications 2023

Advantages

Di-, tri-, and tetra-substituted alkenes

Di-, tri-, and tetra-substituted allenes

Tri-substituted ketenimines

High regio-, diastereo-, and enantioselectivities