Amphiphilic Porphyrin-Camptothecin Supramolecular Nanoparticles

Tumor-targeted co-delivery

Host-guest complexation between porphyrin and camptothecin enhances photodynamic efficiency and chemotherapy, while cancer cell membrane coating provides homologous targeting.

Wang, Shuping · Huang, Xuechun · He, Yunhong · Haotian, Zhang · Jun, Zhou · Guping, Tang · Li, Shijun · Bai, Hongzhen

Nano Today 2023

Advantages

Enhanced solubility of camptothecin

Promoted singlet oxygen production of porphyrin

Cancer cell membrane coating endows homologous targeting