Drives ketolysis and tumor growth
A rate-limiting ketolysis enzyme activated by succinylation, driving ketone body utilization and tumor growth in liver cancer.
Guo, Dong · Tong, Yingying · Qian, Xu · Meng, Ying · Ye, Fei · Jiang, Xiaoming · Wu, Lihui · Yang, Qingqing · Li, Min · Wu, Qingang · Liwei, Xiao · Xuxiao, He · Dou, Nie · Luo, Shudi · Ma, Leina · Liu, Zhihua · Liang, Xiao · Yan, Dong · Lu, Zhimin
Molecular Cell 2025
OXCT1 is succinylated at K421 and activated
SUCLA2-regulated OXCT1 activation significantly enhances ketolysis and HCC cell proliferation
Acetohydroxamic acid (OXCT1 inhibitor) inhibits liver tumor growth in mice and enhances lenvatinib therapy